DNA-encoded chemical libraries (DELs) have emerged as a transformative technology in drug discovery, offering unparalleled efficiency in the identification of bioactive small molecules. By covalently ...
Nowadays, there's lots of buzz about spectacular new medical treatments such as personalised cancer therapy with modified immune cells or antibodies. Such treatments, however, are very complex and ...
To find novel BET BD1 binders, we screened >4.5 billion molecules from our DNA-encoded chemical libraries with BRDT-BD1 or BRDT-BD2 proteins in parallel. A compound series enriched only by BRDT-BD1 ...
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