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Glucocerebrosidase - Wikipedia
The lysosomal transporter and integral membrane protein LIMP-2 (Lysosomal Integral Membrane Protein 2) was shown to bind GCase and facilitate transport to the lysosome, demonstrating a …
Glucocerebrosidase: Functions in and Beyond the Lysosome
Glucocerebrosidase (GCase) is a retaining β-glucosidase with acid pH optimum metabolizing the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose.
Glucocerebrosidase mutations disrupt the lysosome and now the ...
Oct 11, 2023 · GCase mutations that affect function in the lysosome lead to the intracellular accumulation of glycolipids, disrupting normal lysosomal function and autophagy, and leading …
Glucocerebrosidase: Function, Deficiency, and Treatment
Aug 1, 2025 · Glucocerebrosidase, often shortened to GCase, is an enzyme that plays a role in the body’s cellular processes. Enzymes are biological catalysts, meaning they accelerate …
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Developing nanobodies as allosteric molecular chaperones of ...
May 27, 2025 · The enzyme glucocerebrosidase (GCase) catalyses the hydrolysis of glucosylceramide to glucose and ceramide within lysosomes.
Glucocerebrosidase Substrate: Its Function & Accumulation
Jul 25, 2025 · Glucocerebrosidase, often abbreviated as GCase, is a lysosomal enzyme responsible for the breakdown of a specific lipid molecule. This enzyme functions within …
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Evaluation of Strategies for Measuring Lysosomal …
Mutations in GBA1, which encode for the protein glucocerebrosidase (GCase), are the most common genetic risk factor for Parkinson's disease and dementia with Lewy bodies. In …