MUSCLE is a tool for multiple sequence comparison by log-expectation, providing high accuracy and speed for sequence alignment.

At the time of writing (late 2021), Muscle v5 has the highest scores on multiple alignment benchmarks including Balibase, Bralibase, Prefab and Balifam. It can align tens of thousands …

MUSCLE stands for MUltiple Sequence Comparison by Log-Expectation. MUSCLE is claimed to achieve both better average accuracy and better speed than ClustalW2 or T-Coffee, …

Muscle is widely-used software for making multiple alignments of biological sequences. Muscle achieves highest scores on Balibase, Bralibase and Balifam benchmark tests and scales to …

The MPI Bioinformatics Toolkit is an interactive web service which offers access to a great variety of public and in-house bioinformatics tools. They are grouped into different sections that …

MUSCLE creates multiple alignments of amino acid or nucleotide sequences. A range of options is provided that give you the choice of optimizing accuracy, speed, or some compromise …

Traditional tools such as Clustal Omega, MAFFT, and earlier versions of MUSCLE rely on progressive alignment strategies that produce a single alignment. Muscle5, in contrast, …

Nov 15, 2022 · I describe Muscle5, a novel algorithm which constructs an ensemble of high-accuracy alignment with diverse biases by perturbing a hidden Markov model and permuting …

Aug 19, 2004 · In a previous paper, we introduced MUSCLE, a new program for creating multiple alignments of protein sequences, giving a brief summary of the algorithm and showing …

MUSCLE documentation